In psoriasis, activated t cells, ultimately in the skin.

In 1979, researchers accidentally discovered that the drug cyclosporine, which suppresses the immune system in bone marrow transplant patients and cleared psoriasis. Since psoriasis is widely recognized as a disease associated with the immune system. The study of the immune system called immunology. As the immune system affect psoriasis? A normal immune system protects the body from invaders by destroying bacteria, viruses and other foreign proteins. In face, psoriasis, immune system osichok and out of place leads to inflammation and accelerated growth of skin cells. Skin cells multiply too quickly and the skin (and joints in some people), lit. Many steps in this misfire immune response directed at a specific procedure, such as

and drugs. One of the goals of treatment to block or change the answer by focusing on very specific immune cells, thus avoiding a broad impact on other parts of the body. For example,

(recipe used to treat psoriasis) binds to the enzyme that is involved in the rapid growth of cells caused by the immune system in psoriasis. But methotrexate affects other body systems, too. New drugs are called, were intended to address a very specific part of the immune system. What is the role of T cells? Psoriasis is lasix for congestive heart failure often called the T-cell disease. This type of immune system cells (which were very important in the process of internal psoriasis. T cells naturally circulate throughout the body to seek foreign substances. These foreign substances, called, usually outside invaders, like bacteria or virus that activates the T- cells, which then initiates the immune response to neutralize the antigen. In psoriasis, activated T cells, ultimately in the skin. It is not clear why this is happening, but it can be directly linked to genetic predisposition in people who develop psoriasis. T cells are activated by two essential interactions. antigen-presenting cells (APC) and reflects the processes of antigen on the surface. In the cell recognizes and targets that antigen. specific antigen or antigens responsible for psoriasis is not known, but some infections (eg strep throat) to establish antigen believed to cause some cases. When APC shows antigen of T cells, other cellular receptors on APC and T interact with a lock and key for T cells are activated. This lock and key mechanism called kostimuliruyuschih way. If the T cells not activated, the immune response and cycle psoriasis never begin. If T cells activated immune response is initiated that leads to the development of skin lesions. One part of this reaction involves the release. Cytokines are proteins that the immune system uses to transmit messages. In psoriasis, cytokines tell skin cells multiply and mature at an accelerated pace. They also went to other reactions, including activation of additional T cells, recruitment of T cells in the skin and release or a cascade of cytokines. As a result, the cycle skin cells grow too quickly, moving to the surface of the skin and accumulate as dead cells (white scale). top, or epidermal, skin layer thickens and develops redness as blood vessels expand and multiply, and blood flow to the skin increases. how the immune system modulated? Co-stimulating ways (think of them as locks and keys for opening and closing of immune reactions), is a good target for new drugs psoriasis psoriasis short circuit. In addition, other immune cells, involved in psoriasis, also in the center attention. For example, some cytokines carry inflammatory messages and help fuel the overall immune response in the skin. Some of these cytokines, such as

-alpha (TNF-alpha), designed to be locked more >> << Now the market. On the other hand, some cytokines that normally inhibit inflammation is absent or present only at low levels in the affected psoriasis skin. Scientists have experimented with increasing the level of these proteins to balance the biochemical composition of the skin. What lies ahead? Psoriasis research benefit from the that psoriasis is controlled by the immune system and respond to drugs that suppress the immune response. Many other diseases and medical problems such as

and rheumatoid arthritis, is caused by the immune system. genes associated with psoriasis also temperature 'associated with rheumatoid arthritis and lupus. Since psoriasis is clearly visible on the skin, the disease makes it an excellent model to study the effectiveness of different drugs that may be useful for other diseases are also associated with the immune system.